{"id":4385,"date":"2019-04-09T13:10:04","date_gmt":"2019-04-09T13:10:04","guid":{"rendered":"https:\/\/cusjc.ca\/catalyst\/?post_type=project&#038;p=4385"},"modified":"2019-04-09T17:51:28","modified_gmt":"2019-04-09T17:51:28","slug":"fighting-recurring-tonsillitis-how-a-team-of-researchers-is-setting-the-groundwork-for-a-strep-vaccine","status":"publish","type":"project","link":"https:\/\/cusjc.ca\/catalyst\/project\/fighting-recurring-tonsillitis-how-a-team-of-researchers-is-setting-the-groundwork-for-a-strep-vaccine\/","title":{"rendered":"Fighting recurring tonsillitis: How a team of researchers is setting the groundwork for a strep vaccine"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; admin_label=&#8221;Section&#8221; _builder_version=&#8221;3.21&#8243; collapsed=&#8221;off&#8221;][et_pb_fullwidth_header title=&#8221;Fighting recurring tonsillitis: How a team of researchers is setting the groundwork for a strep vaccine&#8221; subhead=&#8221;Researchers in California found a molecular weapon used by strep bacteria to harm throat tissue&#8221; header_fullscreen=&#8221;on&#8221; admin_label=&#8221;Fullwidth Header&#8221; _builder_version=&#8221;3.21&#8243; title_font=&#8221;||||||||&#8221; title_font_size=&#8221;42px&#8221; subhead_font=&#8221;||||||||&#8221; subhead_font_size=&#8221;23px&#8221; background_image=&#8221;https:\/\/cusjc.ca\/catalyst\/wp-content\/uploads\/2019\/04\/tonsilis-1.jpeg&#8221; parallax=&#8221;on&#8221;]<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>By Kiera Kowalski and Levi Garber<\/strong><\/p>\n<p>[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.0.47&#8243; collapsed=&#8221;off&#8221;][et_pb_row _builder_version=&#8221;3.21&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_text _builder_version=&#8221;3.21&#8243;]<\/p>\n<p><strong>Jessica Mayenburg was celebrating her eighteenth birthday at her parents\u2019 home in Carp, Ont. the first time her throat closed up from the tonsillitis she had been fighting for four months.<\/strong><\/p>\n<p><span>Mayenburg went to the bathroom, opened her mouth and stared at the bulging masses of tissue blocking her airway. \u00a0\u00a0\u00a0 <\/span><\/p>\n<p><span>\u201cI could still kind of breathe but it almost felt like someone was sitting on my chest,\u201d she said. \u201cMy lungs were fine but I couldn\u2019t pull any air in.\u201d<\/span><\/p>\n<p><span>Mayenburg, now 21, told her mother she needed to go to the emergency room, and fast.<\/span><\/p>\n<p><span>Even with antibiotics, her body wasn\u2019t able to fight off the infection, and now it wasn\u2019t even able to cope with breathing. <\/span><\/p>\n<p><span>Mayenburg\u2019s story is unfortunately all too common.<\/span><\/p>\n<p><span>Recurring tonsillitis caused by Streptococcus bacteria, commonly referred to as strep throat, is a condition that affects nearly 600 million children worldwide every year. Yet doctors and medical researchers are only now beginning to understand the complexities of the illness. Scientists at the Jolla Institute for Immunology in San Diego, California recently pinpointed a molecule produced by the strep bacteria that wreaks havoc on tonsil tissue in children who are susceptible to frequent infections. That discovery could pave the way for the development of a strep throat vaccine, according to a study published in February in the journal <em>Science Translational Medicine<\/em>. <\/span><\/p>\n<p><span>If realized, a strep vaccine could prevent the recurring throat infections that plague susceptible children. Children like Mayenburg.<\/span><\/p>\n<p><span>\u201cFor the first 17 years of my life, I had strep or tonsillitis every six months or so,\u201d said Mayenburg.<\/span><\/p>\n<p><span>Tonsillitis is the inflammation of the two oval-shaped pads of lymph tissue in the back of the throat that act as filters for the body\u2019s immune system. The condition causes sore throat, fever and trouble breathing. It can be caused by a variety of infections . Streptococcus bacteria cause a form of tonsillitis called strep throat.<br \/><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.21&#8243;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_text _builder_version=&#8221;3.21&#8243;]<\/p>\n<p><span>\u201cI always had other kids at school be like \u2018Oh, you have such a bad immune system, you\u2019re so sick all of the time,'&#8221; said Mayenburg.<\/span><\/p>\n<p><span>\u201cPeople would make fun of me for being sick.\u201d<\/span><\/p>\n<p><span>Some children are more susceptible to contracting strep throat than others because, as researchers at the La Jolla Institute found, they are genetically predisposed to have smaller germinal centres, which are important for development of immune cells.<\/span><\/p>\n<p><span>When a child is susceptible to strep throat, which comes from the bacteria known as Group A Streptococcus, their immune system struggles to produce antibodies to fight off the infection. For Mayenburg, this became a persistent battle.<\/span><\/p>\n<p><span>In September of her first year of university, Mayenburg contracted a particularly bad case of strep throat that turned into tonsillitis. She went to the campus clinic, received antibiotics and her symptoms faded within days. A week later, the symptoms came back.<\/span><\/p>\n<p><span>So Mayenburg was given more antibiotics.<\/span><\/p>\n<p><span>She continued this cycle of getting sick and taking medication until December of that year, when her body could no longer handle the damage caused by persistent rounds of antibiotics. They had killed off so much bacteria in her gut and intestines that Mayenburg was experiencing internal bleeding.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_code _builder_version=&#8221;3.21&#8243;]<\/p>\n<div class=\"piktowrapper-embed\" style=\"height: 300px; position: relative;\" data-uid=\"37725450-untitled-infographic\">\n<div class=\"pikto-canvas-wrap\">\n<div class=\"pikto-canvas\">\n<div class=\"embed-loading-overlay\" style=\"width: 100%; height: 100%; position: absolute; text-align: center;\"><img decoding=\"async\" width=\"60px\" alt=\"Loading...\" style=\"margin-top: 100px\" src=\"https:\/\/create.piktochart.com\/loading.gif\"\/><\/p>\n<p style=\"margin: 0; padding: 0; font-family: Lato, Helvetica, Arial, sans-serif; font-weight: 600; font-size: 16px\">Loading&#8230;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><script>(function(d){var js, id=\"pikto-embed-js\", ref=d.getElementsByTagName(\"script\")[0];if (d.getElementById(id)) { return;}js=d.createElement(\"script\"); js.id=id; js.async=true;js.src=\"https:\/\/create.piktochart.com\/assets\/embedding\/embed.js\";ref.parentNode.insertBefore(js, ref);}(document));<\/script>[\/et_pb_code][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.21&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_text _builder_version=&#8221;3.21&#8243;]<\/p>\n<p>\u00a0<span style=\"font-size: 14px;\">By January, Mayenburg saw an ear nose and throat specialist who put her on a waitlist for tonsil removal surgery, called a tonsillectomy. But the waitlist was nine months long.<\/span><\/p>\n<p><span>And that\u2019s when the tonsillitis became life-threatening, leading to Mayenburg\u2019s birthday visit to the ER.<\/span><\/p>\n<p><span>\u201cI would have to go to the hospital and get steroid shots to decrease the swelling because my airway would close,\u201d said Mayenburg.<\/span><\/p>\n<p><span>After multiple trips to the emergency room for steroid injections, Mayenburg was fast-tracked for an emergency tonsillectomy. She finally had her tonsils removed in March, 2016, seven months after the tonsillitis episodes began.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.21&#8243;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_text _builder_version=&#8221;3.21&#8243;]<\/p>\n<p><span>It is cases like these that have motivated researchers like Jolla Institute for Immunology\u2019s Dr. Jennifer Dan to search for a vaccine against strep throat. That way infections can be prevented long before they get out of hand.<\/span><\/p>\n<p><span>Dan, the lead researcher of the strep vaccine study, said her team found that children who are prone to developing tonsillitis produce fewer antibodies against a harmful protein created by the strep bacteria. That protein, called SpeA, hobbles a patient\u2019s immune system so that it can\u2019t make defensive antibodies that protect against invading bacteria.<\/span><\/p>\n<p><span>Those antibodies are built by white blood cells, known as B cells that fight off bacteria and viruses, Dan explained. The B cells reprogram the immune system to generate a response and create antibodies that target specific infections.<\/span><\/p>\n<p><span>\u201cBasically it\u2019s a series of fine tuning events in order to make a better antibody response,\u201d said Dr. Dan in a phone interview.<\/span><\/p>\n<p><span>Dr. Shane Crotty, who collaborated with Dan on the study, said that discovering SpeA could form the basis for the development of a strep vaccine.<\/span><\/p>\n<p><span>\u201cWe\u2019re definitely excited that there\u2019s a new potential target,\u201d said Dr. Crotty, referring to the harmful SpeA protein.<\/span><\/p>\n<p><span><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_image src=&#8221;https:\/\/cusjc.ca\/catalyst\/wp-content\/uploads\/2019\/04\/EMERG.jpg&#8221; _builder_version=&#8221;3.21&#8243;][\/et_pb_image][et_pb_text _builder_version=&#8221;3.21&#8243; text_font=&#8221;||||||||&#8221; text_font_size=&#8221;11px&#8221;]<\/p>\n<p style=\"text-align: center;\"><strong>Jessica Mayenburg was rushed to the ER many times for steroid shots to open up her throat after it closed due to recurrent tonsillitis. [Photo \u00a9 Levi Garber]<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.21&#8243;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_image src=&#8221;https:\/\/cusjc.ca\/catalyst\/wp-content\/uploads\/2019\/04\/EMERG2.jpg&#8221; _builder_version=&#8221;3.21&#8243;][\/et_pb_image][et_pb_text _builder_version=&#8221;3.21&#8243; text_font=&#8221;||||||||&#8221; text_font_size=&#8221;11px&#8221;]<\/p>\n<p style=\"text-align: center;\"><strong>The otolaryngology department, otherwise known as the ear, nose and throat ward, is where patients at the Ottawa Civic Hospital seek treatment for Strep Throat. [Photo \u00a9 Levi Garber]<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_text _builder_version=&#8221;3.21&#8243;]<\/p>\n<p><span style=\"font-size: 14px;\">If and when researchers start working towards the vaccine, they would most likely develop a vaccine similar to the one against tetanus. That vaccine teaches a person\u2019s immune system to recognize toxins released by the bacteria, instead of teaching the immune system to recognize the bacteria itself.<\/span><\/p>\n<p><span>In the past, a potential vaccine target for strep throat had been the Streptococcus bacteria itself. Now researchers can use the strep toxin SpeA to train the immune system how to fight the pathogen. Dr. Crotty believes this strategy has a chance at success. <\/span><span>\u00a0<\/span><\/p>\n<p><span>By designing a vaccine based on the common toxic weapon carried by all these bacteria \u2013 the protein SpeA \u2013 instead of the surface features of a particular strep strain, the immune system could learn to kill a variety of strep strains.<\/span><\/p>\n<p>\u201cThere are a hundred different strains of Group A strep that can infect people because their surfaces all look a little bit different, like they\u2019re wearing different coloured clothes essentially,\u201d Crotty said.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.21&#8243;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_text _builder_version=&#8221;3.21&#8243;]<\/p>\n<p><span>Crotty added that, like the common cold virus, there\u2019s no way to tell what strains of strep might spread across a certain area in any given year.<\/span><\/p>\n<p><span>\u201cEssentially you\u2019re ignoring whether different strains have different surfaces\u2014[that is] if they\u2019re showing up with different clothes on,\u201d he said.<\/span><\/p>\n<p><span><\/span><\/p>\n<p><strong>Next steps<\/strong><\/p>\n<p><span>Despite having identified a strep vaccine target, Crotty said it\u2019s not necessarily smooth sailing from here. Vaccine development can take up to 10 or 20 years, and requires rigorous research and expensive clinical trials, he added.<\/span><\/p>\n<p><span>\u00a0<\/span><span>Dr. Jodi Jones, an ears nose and throat doctor at the Health Sciences Centre in Winnipeg, said that although the idea of a strep vaccine is promising, it\u2019s still too far in the future to plan for now.<\/span><span>\u00a0<\/span><\/p>\n<p><span>\u201cI perform around 130 tonsillectomies a year,\u201d said Dr. Jones. \u201cA vaccine would definitely be helpful for both patients and doctors.\u201d<\/span><\/p>\n<p><span>But children who\u2019ve experienced strep like Mayenburg may have a long ways to wait before a vaccine is available.<\/span><span>\u00a0<\/span><\/p>\n<p><span>For Mayenburg, a vaccine that could help children avoid the months and years of the physical pain and mental anguish associated with recurrent tonsillitis is worth the wait.<\/span><\/p>\n<p><span>\u201cI think it would be really cool if they could because there are a lot of kids that have it through their whole life,\u201d she said.<\/span><\/p>\n<p><span>\u201cIt can affect your quality of life as a kid to be sick all the time.\u201d<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;3.21&#8243;][et_pb_code _builder_version=&#8221;3.21&#8243;]<\/p>\n<div class=\"infogram-embed\" data-id=\"b06dfc87-5d36-4798-9c4e-5041f8f44ac0\" data-type=\"interactive\" data-title=\"STREP\"><\/div>\n<p><script>!function(e,t,s,i){var n=\"InfogramEmbeds\",o=e.getElementsByTagName(\"script\")[0],d=\/^http:\/.test(e.location)?\"http:\":\"https:\";if(\/^\\\/{2}\/.test(i)&&(i=d+i),window[n]&&window[n].initialized)window[n].process&&window[n].process();else if(!e.getElementById(s)){var r=e.createElement(\"script\");r.async=1,r.id=s,r.src=i,o.parentNode.insertBefore(r,o)}}(document,0,\"infogram-async\",\"https:\/\/e.infogram.com\/js\/dist\/embed-loader-min.js\");<\/script><\/p>\n<div style=\"padding:8px 0;font-family:Arial!important;font-size:13px!important;line-height:15px!important;text-align:center;border-top:1px solid #dadada;margin:0 30px\"><a href=\"https:\/\/infogram.com\/b06dfc87-5d36-4798-9c4e-5041f8f44ac0\" style=\"color:#989898!important;text-decoration:none!important;\" target=\"_blank\" rel=\"noopener noreferrer\">STREP<\/a><br \/><a href=\"https:\/\/infogram.com\" style=\"color:#989898!important;text-decoration:none!important;\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Infogram<\/a><\/div>\n<p>[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers in California found a chemical weapon used by strep bacteria to harm throat tissue<\/p>\n","protected":false},"author":58,"featured_media":4400,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:paragraph -->\n<p><strong>By Kiera Kowalski and Levi Garber<\/strong><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Jessica Mayenburg was celebrating her\neighteenth birthday at her parents\u2019 home in Carp, Ont. the first time her\nthroat closed up from the tonsillitis she had been fighting for four months.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Mayenburg went to the bathroom, opened her\nmouth and stared at the bulging masses of tissue blocking her airway. &nbsp;&nbsp;&nbsp; <\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cI could still kind of breathe but it almost\nfelt like someone was sitting on my chest,\u201d she said. \u201cMy lungs were fine but I\ncouldn\u2019t pull any air in.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Mayenburg, now 21, told her mother she needed\nto go to the emergency room, and fast.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Even with antibiotics, her body wasn\u2019t able to\nfight off the infection, and now it wasn\u2019t even able to cope with breathing.\nMayenburg\u2019s story is unfortunately all too common.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Recurring tonsillitis caused by Streptococcus\nbacteria, commonly referred to as strep throat, is a condition that affects\nnearly 600 million children worldwide every year. Yet doctors and medical\nresearchers are only now beginning to understand the complexities of the\nillness. Scientists at the Jolla Institute for Immunology in San Diego,\nCalifornia recently pinpointed a molecule produced by the strep bacteria that\nwreaks havoc on tonsil tissue in children who are susceptible to frequent\ninfections. That discovery could pave the way for the development of a strep\nthroat vaccine, according to a study published in February in the journal <em>Science Translational Medicine<\/em>. <\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>If realized, a strep vaccine could prevent the\nrecurring throat infections that plague susceptible children. Children like\nMayenburg.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cFor the first 17 years of my life, I had\nstrep or tonsillitis every six months or so,\u201d said Mayenburg.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Tonsillitis is the inflammation of the two\noval-shaped pads of lymph tissue in the back of the throat that act as filters\nfor the body\u2019s immune system. The condition causes sore throat, fever and\ntrouble breathing. Strep throat is the combination of bacterial infection by\nthe Streptococcus bacteria that causes tonsillitis.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:html -->\n<div class=\"piktowrapper-embed\" style=\"height: 300px; position: relative;\" data-uid=\"37725450-untitled-infographic\"><div class=\"pikto-canvas-wrap\"><div class=\"pikto-canvas\"><div class=\"embed-loading-overlay\" style=\"width: 100%; height: 100%; position: absolute; text-align: center;\"><img width=\"60px\" alt=\"Loading...\" style=\"margin-top: 100px\" src=\"https:\/\/create.piktochart.com\/loading.gif\"\/><p style=\"margin: 0; padding: 0; font-family: Lato, Helvetica, Arial, sans-serif; font-weight: 600; font-size: 16px\">Loading...<\/p><\/div><\/div><\/div><\/div><script>(function(d){var js, id=\"pikto-embed-js\", ref=d.getElementsByTagName(\"script\")[0];if (d.getElementById(id)) { return;}js=d.createElement(\"script\"); js.id=id; js.async=true;js.src=\"https:\/\/create.piktochart.com\/assets\/embedding\/embed.js\";ref.parentNode.insertBefore(js, ref);}(document));<\/script>\n<!-- \/wp:html -->\n\n<!-- wp:paragraph -->\n<p>\u201cI always had other kids at school be like\n\u2018Oh, you have such a bad immune system, you\u2019re so sick all of the time.\u2019\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cPeople would make fun of me for being sick.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Some children are more susceptible to\ncontracting strep throat than others because, as researchers at the La Jolla\nInstitute found, they are genetically predisposed to have smaller germinal\ncentres, which are important for development of immune cells.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>When a child is susceptible to strep throat,\nwhich comes from the bacteria known as Group A Streptococcus, their immune\nsystem struggles to produce antibodies to fight off the infection. For\nMayenburg, this became a persistent battle.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>In September of her first year of university,\nMayenburg contracted a particularly bad case of strep throat that turned into\ntonsillitis. She went to the campus clinic, received antibiotics and her\nsymptoms faded within days. A week later, the symptoms came back.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>So Mayenburg was given more antibiotics.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>She continued this cycle of getting sick and\ntaking medication until December of that year, when her body could no longer\nhandle the damage caused by persistent rounds of antibiotics. They had killed\noff so much bacteria in her gut and intestines that Mayenburg was experiencing\ninternal bleeding.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>By January, Mayenburg saw an ear nose and\nthroat specialist who put her on a waitlist for tonsil removal surgery, called\na tonsillectomy. But the waitlist was nine months long.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>And that\u2019s when the tonsillitis became\nlife-threatening, leading to Mayenburg\u2019s birthday visit to the ER.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cI would have to go to the hospital and get\nsteroid shots to decrease the swelling because my airway would close,\u201d said\nMayenburg.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>After multiple trips to the emergency room for\nsteroid injections, Mayenburg was fast-tracked for an emergency tonsillectomy.\nShe finally had her tonsils removed in March, 2016, seven months after the\ntonsillitis episodes began.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>It is cases like these that have motivated\nresearchers like Jolla Institute for Immunology\u2019s Dr. Jennifer Dan to search\nfor a vaccine against strep throat. That way infections can be prevented long\nbefore they get out of hand.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Dan, the lead researcher of the strep vaccine\nstudy, said her team found that children who are prone to developing\ntonsillitis produce fewer antibodies against a harmful protein created by the\nstrep bacteria. That protein, called SpeA, hobbles a patient\u2019s immune system so\nthat it can\u2019t make defensive antibodies that protect against invading bacteria.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Those antibodies are built by white blood\ncells, known as B cells that fight off bacteria and viruses, Dan explained. The\nB cells reprogram the immune system to generate a response and create\nantibodies that target specific infections.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cBasically it\u2019s a series of fine tuning events\nin order to make a better antibody response,\u201d said Dr. Dan in a phone\ninterview. <\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Dr. Shane Crotty, who collaborated with Dan on\nthe study, said that discovering SpeA could form the basis for the development\nof a strep vaccine.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cWe\u2019re definitely excited that there\u2019s a new\npotential target,\u201d said Dr. Crotty, referring to the harmful SpeA protein.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>If and when researchers start working towards\nthe vaccine, they would most likely develop a vaccine similar to the one\nagainst tetanus. That vaccine teaches a person\u2019s immune system to recognize\ntoxins released by the bacteria, instead of teaching the immune system to\nrecognize the bacteria itself.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>In the past, the potential vaccine target for\nstrep throat had been the Streptococcus bacteria itself. Now researchers can\nuse the strep toxin SpeA to train the immune system how to fight the pathogen. Dr.\nCrotty believes this strategy has a chance at success. <\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>By designing a vaccine based on the common\ntoxic weapon carried by all these bacteria \u2013 the protein SpeA \u2013 instead of the\nsurface features of a particular strep strain, the immune system could learn to\nkill a variety of strep strains.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cThere are a hundred different strains of\nGroup A strep that can infect people because their surfaces all look a little\nbit different, like they\u2019re wearing different coloured clothes essentially,\u201d\nCrotty said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Crotty added that, like the common cold virus,\nthere\u2019s no way to tell what strains of strep might spread across a certain area\nin any given year.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cEssentially you\u2019re ignoring whether different\nstrains have different surfaces\u2014[that is] if they\u2019re showing up with different\nclothes on,\u201d he said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Despite having identified a strep vaccine\ntarget, Crotty said it\u2019s not necessarily smooth sailing from here. Vaccine\ndevelopment can take up to 10 or 20 years, and requires rigorous research and\nexpensive clinical trials, he added.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Dr. Jodi Jones, an ears nose and throat doctor\nat the Health Sciences Centre in Winnipeg, said that although the idea of a\nstrep vaccine is promising, it\u2019s still too far in the future to plan for now.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cI perform around 130 tonsillectomies a year,\u201d\nsaid Dr. Jones. \u201cA vaccine would definitely be helpful for both patients and\ndoctors.\u201d<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>So children who\u2019ve experienced strep like\nMayenburg may have a long ways to wait before a vaccine is available.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>For Mayenburg, a vaccine that could help children\navoid the months and years of the physical pain and mental anguish associated\nwith recurrent tonsillitis is worth the wait.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cI think it would be really cool if they could\nbecause there are a lot of kids that have it through their whole life,\u201d she said.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>\u201cIt can affect your quality of life as a kid\nto be sick all the time.\u201d<\/p>\n<!-- \/wp:paragraph -->","_et_gb_content_width":"","footnotes":""},"project_category":[135],"project_tag":[],"class_list":["post-4385","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-feature"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.3 - 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